In recent years, kratom has become an increasingly popular recreational drug around the world; consequently, this increase in popularity is matched by increasing concern over its potential to worsen the current opioid epidemic. As a result, further studies of kratom and its constituent compounds are necessary to better understand the mechanisms of action of these compounds and to evaluate possible therapeutic benefits of mitragynine or 7-hydroxymitragynine, present in kratom. Learn more in this application note.
Preparative chromatography, a method used to separate and purify target compounds from complex mixtures, plays a crucial role in the chemical and pharmaceutical industries. In either industry, preparative chromatography has roles in the early stages of drug development, pilot studies, and process development. In this article, you'll learn how we provide support throughout this process and enable our customers and partners to achieve their purification goals from the milligrams to the kilogram scale.
When choosing a high performance liquid chromatography (HPLC) system, it's important to consider how your future needs may evolve from your current needs. In this article, you’ll learn about the advantages of modular HPLC systems when it comes to current experimental needs and how the ability to swap out HPLC components safeguards the future of your system and your research.
Liquid chromatography (LC) is the standard method used for purifying products in the discovery stages, as it is cost-effective, relatively simple to perform, and reliable. However, obtaining high purity and yield using this approach often comes at the cost of throughput, as purification runs must be lengthened to achieve greater separation between components. This article explores how users can enhance fraction collection efficiency and streamline the purification process by using the latest advances.
Using the right systems can improve sample integrity in your sample separation workflows, helping labs to have greater confidence in their results. Here we outline what to look for in your sample separation instruments to remove risks of common threats to sample integrity.
In this video, you will learn about the benefits of Centrifugal Partition Chromatography (CPC) as it relates to other forms of traditional sample separation. Without solid support, liquid-liquid chromatography allows for repeat injections of samples with 100% recovery of the materials--and you'll never need to replace any silica columns. CPC columns tackle tough separations of complex samples in a single step without prior purification, making it an ideal choice for natural product isolation, protein purification, and more.
While more than 220 viruses are known to infect humans, clinically approved antiviral drugs are available for only a dozen of these viruses. CPC is an ideal solution for natural compound investigations. Gilson, in collaboration with Brazilian researchers, recently performed preliminary experiments demonstrating the antiviral activity of compounds that were fractionated from a plant crude extract using CPC. Read more about the study here.
In this article, we hear from an industry leader on their experience using centrifugal partition chromatography (CPC) in the pharmaceutical industry, and how it's a method well-suited for producing highly active molecules that meet safety and performance requirements.
Lignin is an abundant phenylpropanoid polymer found in all plant matter. It has historically been treated as an impurity in the paper pulping and ethanol biorefinery industries where it is burned as a low-value fuel or sold at low prices. However, developing higher-value applications of lignin would help biorefineries operate at higher efficiencies. In this app note, a two-dimensional separation is conducted using centrifugal partition chromatography (CPC), which helps demonstrate the value of CPC as a tool for gaining deeper insights into depolymerization mixtures for biomass facilities.
The separation power and versatility of centrifugal partition chromatography (CPC) enables many applications in any extraction laboratory setting. In the cannabis field, CPC has provided a cost-effective solution for scalable d9-THC remediation of cannabis oils and extracts. In this webinar, we present application-specific results using CPC for various isolations, highlighting the value of CPC for any cannabis extraction laboratory.