Clinical Research

ELISA protocols rely on precise, repetitive pipetting steps that can quickly become time-consuming. This article explores how PIPETMAN® M96 enables simultaneous 96-well dispensing to streamline plate preparation, reduce variability, and cut pipetting time by up to 70%.

To validate a novel, non-targeted diagnostic method for preeclampsia, researchers at UTCBS needed to process 263 clinical samples across 16,000+ wells. With PIPETMAX® 268, they successfully automated their liquid handling workflow, improving throughput, conserving sample volume, and enabling the statistical reproducibility necessary for meaningful machine learning analysis.

In this technical note, the use of a PIPETMAX® 268 automated liquid handling system is described for the pipetting of the plasma from the whole blood sample. PIPETMAX can be used to aspirate a precise volume of the plasma and transfer this to a suitable analysis or storage tube. If the specific laboratory workflow will benefit from it, then diluent can also be added to the analysis tubes, and the plasma can be mixed into the diluent as part of the same method.

Switching from a manual to an automated process not only enables significantly more effective use of personnel time, but also removes operator error for reproducible results and increases the accuracy and precision of assays. In this article, we delve into the challenges that can arise during this transition and explain how Gilson's solutions and services can ease the process of transferring your manual methods to an automated system.

The type of pipette you use, and your pipetting technique will have a major impact on the accuracy and results of your assays. Almost every laboratory that conducts research will have a pipetting procedure that accurately measures the exact volumes when aspirating and dispensing liquids. However, if the workflow calls for pipetting dense liquids, making sure you’re using the correct pipette can ensure accuracy in your assays.

When pipetting small volumes, you'll need to take additional steps to improve your sampling accuracy. Here are five tips for improving your pipetting technique.

Kinase profiling is a necessary process to confirm inhibitor selectivity and assess off-target activity. The arduous task of optimizing kinase reactions and maintaining a library of enzymes often results in the outsourcing of kinase profiling activities. This poster breaks down a flexible workflow for the automation of bioluminescent kinase selectivity profiling.

Automation of the Kinase Selectivity Profiling System with PIPETMAX 268, in conjunction with automated detection and data analysis methods, offers a streamlined workflow for single-point and dose-response evaluation of potential cancer therapies. Learn more in this application note.

This application note describes a high throughput sample preparation procedure for global glycan mass profiling.