Switching from a manual to an automated process not only enables significantly more effective use of personnel time, but also removes operator error for reproducible results and increases the accuracy and precision of assays. In this article, we delve into the challenges that can arise during this transition and explain how Gilson's solutions and services can ease the process of transferring your manual methods to an automated system.

Synthetic oligonucleotides (oligos) are central to many cutting-edge biochemical applications across research and therapeutics. While solid-phase synthesis typically yields oligos with relatively high purity, they usually need further purification to avoid unintended side-reactions and interferences in downstream applications. Preparative HPLC is the preferred method for small to medium length oligos (10-60 bp). To increase productivity and maximize the profitability of your oligo research and development, finding the optimal LC purification platform is crucial.

Oligonucleotides are core components of many molecular biology tools available today, including antisense gene therapy and primers for qPCR. Depending on the application, highly pure oligos are typically required, or experiments lack reproducibility — and for applications such as therapeutics, the consequences can be dire. To ensure that oligos are at the desired level of purity for their application, you need to use effective purification techniques. HPLC is one of the most effective and versatile approaches available for oligo purification, and in this article, we cover five tips to help improve your HPLC workflow to help you achieve highly pure oligos every time.

For labs looking to uncover weak protein interactions, conventional methods aren’t ideal. Consider exclusion-based sample preparation from EXTRACTMAN instead.

Automating protocols with liquid handlers provides repeatability and gives you greater confidence in your results. Here's a quick overview of automated SPE.

Analyzing the use of AttractSPE WAX-PFA cartridges with the Gilson 274 ASPEC Large Volume System to automate the SPE of PFAs from tap water samples.

Laboratories can increase precision while automating many of their tasks using robotic liquid handling systems. Here's how you should choose your solution.

The type of pipette you use, and your pipetting technique will have a major impact on the accuracy and results of your assays. Almost every laboratory that conducts research will have a pipetting procedure that accurately measures the exact volumes when aspirating and dispensing liquids. However, if the workflow calls for pipetting dense liquids, making sure you’re using the correct pipette can ensure accuracy in your assays.

A growing drug discovery and biotech market requires labs to realize OEM partnership benefits more than ever. Consider these benefits available to help you.

When pipetting small volumes, you'll need to take additional steps to improve your sampling accuracy. Here are five tips for improving your pipetting technique.